–Kindle Vildor started at CB in place of the injured Terrion Arnold. Get well soon, Terrion, you were missed…
– On the Colts' second scoring drive, with the Lions leading 7-3, Anthony Richardson hit TE Drew Ogletree with both hands in the end zone, but Ogletree dropped him. The Colts offense never really recovered from that. They settled for a short FG, which would be their last points.
– In the second half, the Colts ran 20 offensive plays and totaled 67 net yards by punting four straight times before being stopped on fourth down on their final drive – where they gained 45 of those 67 yards.
– Left tackle Taylor Decker briefly left the game with a knee and ankle injury when Jared Goff was released. Graham Glasgow hit the ball to left tackle for a play while Michael Niese came in at Glasgow's left guard position. That only lasted one play before Dan Skipper – who was beaten for a sack on the play that left Decker injured – came into the game at left tackle and Glasgow returned to LG. Decker moved back to left tackle.
–Jake Bates was perfect on field goals, hitting a 56-yarder that would have been good from a distance.
—From the inactive listRookie Christian Mahogany played ahead of experienced reserve IOL Kayode Awosika. This is Mahogany's first time playing in the NFL.
–The Colts ran just 47 offensive plays, and 26 of them came in the first 22 minutes of the 60-minute game.
– The Lions did not record a sack against Anthony Richardson while Indianapolis sacked Goff three times.
–Indianapolis recorded five TFLs on run plays in the game, the most the Lions have allowed all season
–Detroit's defense hasn't allowed a touchdown in 10 quarters
–Detroit lost return man/wide receiver Kalif Raymond due to a foot injury on a punt return. He was quickly excluded.
–Over the last five weeks, the Lions have outscored their opponents by an average of 35.6 to 12.6
–Detroit swept the AFC South with the win in Indianapolis
