Star pass catcher George Kittle and the San Francisco 49ers face the Buffalo Bills on Sunday at 8:20 p.m. ET at Highmark Stadium.
The Bills field the seventh-ranked defense this season (19.5 points allowed per game) and have been more effective on the other side of the ball, where they ranked third-best with 29.1 points per game. From an offensive standpoint, the 49ers score 23.6 points per game (13th). On the other side of the ball, they rank 20th in the NFL (23.6 points given up per game).
Bills vs. 49ers: Live streaming information, TV channel and game time
Bills vs. 49ers betting lines
NFL odds courtesy of BetMGM. Odds updated at 8:21 p.m. ET on Saturday. For a complete list of sports betting odds, see USA TODAY Sports Betting Results Odds Hub.
- Distribution favorite: Invoices (-6)
- Money line: Bills (-277), 49ers (+226)
- In total: 44.5 points
Gannett may earn revenue from sports betting operators for referring viewers to betting services. Sports betting providers have no influence on the newsrooms or reporting and are in no way dependent on these revenues. General terms and conditions apply. The general terms and conditions can be found on the operator's website. If you or someone you know has a gambling problem, help is available. Call the National Council on Problem Gambling 24 hours a day at 1-800-GAMBLER (NJ, OH), 1-800-522-4700 (CO), 1-800-BETS-OFF (IA), 1-800- 9- on. WITH-IT (IN). You must be at least 21 years old to play. Sports betting and gambling are not legal everywhere. Make sure you comply with the laws where you live.
We may occasionally recommend products and services that may be of interest to you. If you make a purchase by clicking one of the links, we may receive an affiliate fee. However, Bills Wire operates independently and this has no influence on our reporting.