When playing on a short week, injuries are always higher because teams simply don't have enough time to properly assess when players are injured and how ready they will be when the game starts three days early.
This week, the Pittsburgh Steelers and Cleveland Browns draw the short straw on Thursday Night Football, and for the Browns, it could have a significant impact on the outcome.
Last week against the New Orleans Saints, starting offensive tackles Jedrick Wills and Dawand Jones were both out. This week the Browns face TJ Watt and Nick Herbig, giving Pittsburgh a big advantage if they can't play the starting offense.
The Browns are also missing their top tackler. Linebacker Jeremiah Owusu-Koramoah went on IR with a neck injury.