The Head into Week 13 looking for a win to end their current two-game losing streak and get a win that can help them continue their season run.
To do so, San Francisco must successfully penetrate one of the NFL's most hostile venues. The 49ers (5-6) travel to (9-2) for a primetime showdown.
San Francisco is . Purdy missed the 49ers' 38-10 loss last week by with a right shoulder injury.
As San Francisco fights to stay in the NFC West race and Buffalo fights to stay within a game of Kansas City for the AFC's No. 1 seed, here's a look at the final day's odds, including point spreads, the total points and the respective point injury reports.
Game odds 49ers vs. Bills:
All NFL odds via BetMGM:
- Point spread: Buffalo -6
- Money line: Buffalo -275, San Francisco +225
- Over-Under: 44.5
49ers vs. Bills injury updates:
- San Francisco DE Nick Bosa – OUT (Hip, Oblique)
- San Francisco DT Jordan Elliott – OUT (concussion)
- San Francisco LB Dre Greenlaw – OUT (Achilles)
- San Francisco CB Deommodore Lenoir – OUT (knee)
- San Francisco OT Trent Williams – OUT (ankle)
- San Francisco LG Aaron Banks – OUT (concussion)
- Buffalo TE Dalton Kincaid – OUT (knee)
- Buffalo WR Keon Coleman – Questionable (Wrist)
49ers vs Bills Prediction, Picks
San Francisco is still trying to get running back Christian McCaffrey back to full nfl Offensive Player of the Year form following his return from injury. Maybe there are some echoes of that in this competition.
Purdy's return should help, but ultimately the injury list elsewhere just feels too long and too significant for San Francisco to overcome on the road against one of the nfl's best teams and best quarterbacks.
Forecast: Buffalo 30, San Francisco 20
49ers vs. Bills channel, start time, streaming:
The 49ers vs. Bills game begins at 5:20 p.m. PT and can be seen on NBC and streamed on Peacock.
For more betting analysis and predictions, visit
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