Australia ruthlessly dismantled India in their first game since their shock semi-final defeat at the T20 World Cup in October.
Led by Tahlia McGrath in place of the injured Alyssa Healy, the hosts bowled India out for just 100 with a good batting wicket before cruising to victory in just 16.2 overs in the first of three one-day internationals.
The five-wicket winning margin flattered India, who were blown away by pace bowler Megan Schutt's career best of 5-19, while only Jemimah Rodrigues managed to pass 20.
In response, openers Phoebe Litchfield and Georgia Voll set the tone with the bat as Australia responded in style to their shock World Cup semi-final defeat to South Africa.
Litchfield dropped 35 off 29 balls before becoming one of Renuka Singh Thakurs' three victims, but 21-year-old debutant Voll ensured Australia got over the line with an unbeaten 46 balls.
The second ODI will take place on Sunday (Saturday, 23:45 GMT) at the same venue – Allan Border Field, Brisbane.